| Monensin and the prevention of tryptophan-induced acute bovine pulmonary edema and emphysema. | |
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MedLine Citation:
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PMID: 663643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3-Methylindole, a ruminal fermentation product of tryptophan, induces acute pulmonary edema and emphysema in cattle, and 3-methylindole is present in the ruminal fluid and blood of cows with a natually occurring form of this disease. Monensin, a polyether antibiotic and widely used feed additive for beef cattle, prevented tryptophan-induced acute bovine pulmonary edema and emphysema. Monensin acted by reducing the ruminal conversion of L-tryptophan to 3-methylindole both in vitro and in vivo. Lasalocid, also a polyether antibiotic, showed similar effects in vitro. These results provide a promising approach to prevention of this major respiratory disease of cattle. |
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Authors:
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A C Hammond; J R Carlson; R G Breeze |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 201 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1978 Jul |
Date Detail:
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Created Date: 1978-09-01 Completed Date: 1978-09-01 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 153-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cattle Furans / therapeutic use* Lasalocid / therapeutic use Monensin / pharmacology, therapeutic use* Pneumonia, Atypical Interstitial, of Cattle / prevention & control* Rumen / metabolism Skatole / metabolism Tryptophan / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Furans; 17090-79-8/Monensin; 25999-31-9/Lasalocid; 73-22-3/Tryptophan; 83-34-1/Skatole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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