Document Detail


Monascusazaphilones A-C, three new azaphilone analogues isolated from the fungus Monascus purpureus BCRC 38108.
MedLine Citation:
PMID:  23013165     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Investigation of the 95% EtOH extract of red yeast rice fermented with the pink mutant of the fungus Monascus purpureus BCRC 38108 led to the isolation of three new azaphilone derivatives, namely monascusazaphilones A-C (1-3), together with two known compounds. Compounds 1-3 were isolated from this species for the first time. Their structures were elucidated by 1-D and 2-D nuclear magnetic resonance spectroscopy together with HR-ESI-MS analysis and comparison of the spectroscopic data with those reported in the literatures. All isolates were evaluated for their inhibitory effects on nitric oxide (NO) production by macrophages. Among the isolates, compound 1 demonstrated stronger inhibition on NO production.
Authors:
Ming-Der Wu; Ming-Jen Cheng; Yi-Jen Yech; Yen-Lin Chen; Kai-Ping Chen; Ping-Hsun Yang; Ih-Sheng Chen; Gwo-Fang Yuan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  Natural product research     Volume:  -     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Bioresource Collection and Research Center, Food Industry Research and Development Institute , Hsinchu 300 , Taiwan , ROC.
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