Document Detail


Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats.
MedLine Citation:
PMID:  16117609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatoprotective effects of momordin Ic and oleanolic acid obtained from Kochiae Fructus (KF), the fruit of a traditional Oriental medicinal plant, were evaluated against carbon tetrachloride (CCl4)-induced liver damage in rats. Male Sprague-Dawley rats were divided into four groups: control, CCl4-treated, CCl4 plus momordin Ic-treated (MMDIc-CCl4), and CCl4 plus oleanolic acid-treated (OAA-CCl4). Momordin Ic (30 mg/kg of body weight) and oleanolic acid (30 mg/kg of body weight) were orally administered once a day for 14 days. A mixture of 0.2 mL/100 g of body weight of CCl4 in olive oil (1:1, vol/vol) was injected 30 minutes after the final administration of momordin Ic and oleanolic acid. The momordin Ic and oleanolic acid pretreatments resulted in significantly lower serum transaminase, lactic dehydrogenase, and gamma-glutamyltransferase levels in the CCl4-treated rats. The CCl4-treated rats had significantly lower activities of glutathione, glutathione reductase, glutathione S-transferase, superoxide dismutase, catalase, and glutathione peroxidase. However, pretreatment with momordin Ic and oleanolic acid reduced the effect of CCl4 and helped maintain levels of the enzymes. Pretreatment with momordin Ic and oleanolic acid resulted in significantly lower production of aminopyrine N-demethylase and aniline hydroxylase in the CCl4-treated rats. Pretreatment with momordin Ic resulted in lower catalase and aminopyrine N-demethylase activity induction by CCl4, towards normalization. Momordin Ic and oleanolic acid obtained from KF appear to contribute to alleviating the adverse effects of CCl4 treatment by enhancing the hepatic antioxidant defense system.
Authors:
Na-Young Kim; Mi-Kyung Lee; Myoung-Ju Park; Seog-Ji Kim; Hee-Jun Park; Jong-Won Choi; Seok-Hwan Kim; Soo-Yeul Cho; Jeong-Sook Lee
Related Documents :
2770059 - Effects of diltiazem on plasma uric acid level and renal uric acid excretion in rats.
8357939 - A high-performance liquid chromatographic method for the determination of hypoxanthine,...
6712409 - Urine uric acid and urine creatine ratio in acute renal failure.
2210989 - Generation of complement-derived anaphylatoxins in normal human donor corneas.
17470699 - Serum concentrations of uric acid and the metabolic syndrome among us children and adol...
18436559 - Preliminary experience with the smooth muscle troponin-like protein, calponin, as a nov...
8704979 - 'fusel' alcohols induce hyphal-like extensions and pseudohyphal formation in yeasts.
8830929 - Enhanced capacity of n-3 fatty acid-enriched macrophages to oxidize low density lipopro...
12137279 - Organic compounds in carbonaceous meteorites.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal food     Volume:  8     ISSN:  1096-620X     ISO Abbreviation:  J Med Food     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-24     Completed Date:  2005-11-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Affiliation:
Department of Food Science and Nutrition, Dong-A University, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Carbon Tetrachloride / antagonists & inhibitors*,  toxicity
Chenopodiaceae / chemistry*
Glutathione / metabolism
Liver / drug effects*,  enzymology,  metabolism
Male
Oleanolic Acid / analogs & derivatives*,  pharmacology*
Protective Agents / pharmacology
Random Allocation
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Protective Agents; 0/momordin I (Oleanolic Acid); 508-02-1/Oleanolic Acid; 56-23-5/Carbon Tetrachloride; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neuroprotective effects of butterbur and rough aster against kainic Acid-induced oxidative stress in...
Next Document:  Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabol...