Document Detail

Momordin Ic and oleanolic acid from Kochiae Fructus reduce carbon tetrachloride-induced hepatotoxicity in rats.
MedLine Citation:
PMID:  16117609     Owner:  NLM     Status:  MEDLINE    
Hepatoprotective effects of momordin Ic and oleanolic acid obtained from Kochiae Fructus (KF), the fruit of a traditional Oriental medicinal plant, were evaluated against carbon tetrachloride (CCl4)-induced liver damage in rats. Male Sprague-Dawley rats were divided into four groups: control, CCl4-treated, CCl4 plus momordin Ic-treated (MMDIc-CCl4), and CCl4 plus oleanolic acid-treated (OAA-CCl4). Momordin Ic (30 mg/kg of body weight) and oleanolic acid (30 mg/kg of body weight) were orally administered once a day for 14 days. A mixture of 0.2 mL/100 g of body weight of CCl4 in olive oil (1:1, vol/vol) was injected 30 minutes after the final administration of momordin Ic and oleanolic acid. The momordin Ic and oleanolic acid pretreatments resulted in significantly lower serum transaminase, lactic dehydrogenase, and gamma-glutamyltransferase levels in the CCl4-treated rats. The CCl4-treated rats had significantly lower activities of glutathione, glutathione reductase, glutathione S-transferase, superoxide dismutase, catalase, and glutathione peroxidase. However, pretreatment with momordin Ic and oleanolic acid reduced the effect of CCl4 and helped maintain levels of the enzymes. Pretreatment with momordin Ic and oleanolic acid resulted in significantly lower production of aminopyrine N-demethylase and aniline hydroxylase in the CCl4-treated rats. Pretreatment with momordin Ic resulted in lower catalase and aminopyrine N-demethylase activity induction by CCl4, towards normalization. Momordin Ic and oleanolic acid obtained from KF appear to contribute to alleviating the adverse effects of CCl4 treatment by enhancing the hepatic antioxidant defense system.
Na-Young Kim; Mi-Kyung Lee; Myoung-Ju Park; Seog-Ji Kim; Hee-Jun Park; Jong-Won Choi; Seok-Hwan Kim; Soo-Yeul Cho; Jeong-Sook Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal food     Volume:  8     ISSN:  1096-620X     ISO Abbreviation:  J Med Food     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-24     Completed Date:  2005-11-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Department of Food Science and Nutrition, Dong-A University, Korea.
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MeSH Terms
Administration, Oral
Carbon Tetrachloride / antagonists & inhibitors*,  toxicity
Chenopodiaceae / chemistry*
Glutathione / metabolism
Liver / drug effects*,  enzymology,  metabolism
Oleanolic Acid / analogs & derivatives*,  pharmacology*
Protective Agents / pharmacology
Random Allocation
Rats, Sprague-Dawley
Reg. No./Substance:
0/Protective Agents; 0/momordin I (Oleanolic Acid); 508-02-1/Oleanolic Acid; 56-23-5/Carbon Tetrachloride; 70-18-8/Glutathione

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