| Moment analysis of hepatic local disposition of allopurinol and oxipurinol: metabolism kinetics from allopurinol to oxipurinol in the rat isolated perfused liver. | |
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MedLine Citation:
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PMID: 7932056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Drug metabolism in the liver was examined by the rat isolated perfused liver using the single-pass bolus-input technique. The test compounds, allopurinol and its metabolite oxipurinol, were independently introduced into the liver from the portal vein, and the concentration profiles in the venous outflow were monitored and kinetically analysed by moment theory. The recovery ratios of allopurinol and oxipurinol after the individual administration of each drug were estimated to be 0.17 (+/- 0.08 s.d.) and 1.03 (+/- 0.02 s.d.), respectively. The outflow recovery ratio of oxipurinol as the metabolite after allopurinol administration was estimated to be 0.80 (+/- 0.07 s.d.). These results indicate that the combined outflow recovery of the precursor and the metabolite after allopurinol administration is almost 100% in the rat liver. |
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Authors:
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H Yasui; K Yamaoka; M Nishimura; S Naito; T Nakagawa |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 46 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-11-21 Completed Date: 1994-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 524-7 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, Kyoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allopurinol
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pharmacokinetics* Animals Injections, Intravenous Liver / metabolism* Male Oxypurinol / pharmacokinetics* Perfusion Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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2465-59-0/Oxypurinol; 315-30-0/Allopurinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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