| Molecularly imprinted polymers as drug delivery systems for the sustained release of glycyrrhizic acid. | |
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MedLine Citation:
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PMID: 20609058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim was to synthesize molecularly imprinted polymers (MIPs) with high recognition properties towards glycyrrhizic acid and to evaluate the performance of these materials to act as base excipients in glycyrrhizic acid sustained release in gastrointestinal simulating fluids. METHODS: MIPs were synthesized using methacrylic acid (MAA) as acidic, 2-(dimethylamino)ethyl methacrylate (DMAEMA) as basic, and 2-hydroxyethylmethacrylate (HEMA) as neutral functional monomers, while ethylene glycol dimethacrylate (EGDMA) was chosen as a crosslinking agent. The imprinting effect was evaluated by binding experiments using glycyrrhizic acid and glycyrrhetic acid (analogue molecule) solutions and in-vitro release studies were performed in gastrointestinal simulating fluids. KEY FINDINGS: Good recognition and selectivity properties were found in all the synthesized materials in both ethanol and ethanol-water mixture. The release from non-imprinted polymers was indeed higher at acidic pH, while a slower release was observed in MIPs' case, because of the presence of imprinted cavities in the polymeric structure. The stronger capacity of MAA to interact by hydrogen bonds with the template makes MAA-containing MIPs the most effective materials in both rebinding and release experiments. CONCLUSIONS: The release tests confirm the applicability of imprinted polymer for glycyrrhizic acid sustained release in gastrointestinal simulating fluids. |
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Authors:
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Giuseppe Cirillo; Ortensia Ilaria Parisi; Manuela Curcio; Francesco Puoci; Francesca Iemma; Umile Gianfranco Spizzirri; Nevio Picci |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 62 ISSN: 2042-7158 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2011-01-31 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 577-82 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Farmaceutiche, Università della Calabria, Arcavacata di Rende (CS), Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical
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methods Delayed-Action Preparations Drug Administration Schedule Drug Carriers / chemistry* Ethanol Gastrointestinal Tract Glycyrrhizic Acid / administration & dosage* Hydrogen Bonding Hydrogen-Ion Concentration Molecular Imprinting* Plant Extracts / administration & dosage Polymers / chemistry* Technology, Pharmaceutical / methods* Time Factors Water |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Drug Carriers; 0/Plant Extracts; 0/Polymers; 1405-86-3/Glycyrrhizic Acid; 64-17-5/Ethanol; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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