| Molecularly imprinted poly[bis(2,2'-bithienyl)methane] film with built-in molecular recognition sites for a piezoelectric microgravimetry chemosensor for selective determination of dopamine. | |
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MedLine Citation:
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PMID: 20471327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A piezoelectric microgravimetry (PM) chemosensor, featuring a film of molecularly imprinted polymer (MIP) of poly[bis(2,2'-bithienyl)methane] bearing either a 3,4-dihydroxyphenyl or benzo-18-crown-6 substituent, for selective determination of dopamine was devised and tested. A Pt/quartz resonator and a dopamine-templated MIP film, deposited by electropolymerization onto an underlayer of poly(bithiophene), served as the transducer and recognition element of the chemosensor, respectively. The UV-vis spectroscopic and XPS as well as electrochemical measurements verified completeness of the dopamine template extraction with a strong base solution. The extraction-generated molecular cavities featured recognition sites that served selective dopamine analyte binding. The SECM imaging substantiated the permeability characteristics of the template-free MIP film. The dopamine analyte was determined under FIA conditions with the PM detection. The lower limit of detection was 10nM dopamine at favorable conditions involving the 35 μL/min carrier solution flow rate and the injected sample volume of 1 mL. The sensitivity of the chemosensor increased almost fivefold when the poly(bithiophene) film coated Pt/quartz electrode was used instead of the bare Pt/quartz electrode as the substrate for deposition of the MIP film. The chemosensor successfully discriminated dopamine from structural and functional analogues, such as 2-phenylethylamine, histamine, and ascorbic acid. The optimum mean thickness of the MIP film was ∼220 nm. |
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Authors:
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Agnieszka Pietrzyk; Subramanian Suriyanarayanan; Wlodzimierz Kutner; Eranda Maligaspe; Melvin E Zandler; Francis D'Souza |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-03-27 |
Journal Detail:
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Title: Bioelectrochemistry (Amsterdam, Netherlands) Volume: 80 ISSN: 1878-562X ISO Abbreviation: Bioelectrochemistry Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100953583 Medline TA: Bioelectrochemistry Country: Netherlands |
Other Details:
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Languages: eng Pagination: 62-72 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ascorbic Acid
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analysis Biosensing Techniques / instrumentation, methods* Crown Ethers / chemistry Dopamine / analysis*, chemistry Electrochemistry Electrodes Histamine / analysis Methane / chemistry* Molecular Imprinting / instrumentation, methods* Phenethylamines / analysis Photoelectron Spectroscopy Platinum / chemistry Polymers / chemistry* Quartz / chemistry Spectrophotometry, Ultraviolet Thiophenes / chemistry* Transducers |
| Chemical | |
Reg. No./Substance:
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0/Crown Ethers; 0/Phenethylamines; 0/Polymers; 0/Thiophenes; 14808-60-7/Quartz; 17455-13-9/18-crown-6; 50-81-7/Ascorbic Acid; 51-45-6/Histamine; 64-04-0/phenethylamine; 74-82-8/Methane; 7440-06-4/Platinum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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