| Molecular wipes: application to epidemic keratoconjuctivitis. | |
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MedLine Citation:
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PMID: 21838327 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Epidemic keratoconjunctivitis (EKC) is a severe disease of the eye, caused by members of the Adenoviridae (Ad) family, with symptoms such as keratitis, conjunctivitis, pain, edema, and reduced vision that may last for months or years. There are no vaccines or antiviral drugs available to prevent or treat EKC. We have found previously that EKC-causing Ads use sialic acid as a cellular receptor, and demonstrated that soluble, sialic acid-containing molecules can prevent infection. In this study, we have synthesized multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) and shown that these constructs are efficient inhibitors of Ad binding (IC50 = 0.9 μM) and Ad infectivity (IC50 = 0.7 μM). We also show that the mechanism of action is to aggregate virus particles and thereby preventing them from binding to ocular cells. We suggest that such formulations may be used for topical treatment of adenovirus-caused EKC. |
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Authors:
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Karolina Aplander; Marko Marttila; Sophie Manner; Niklas Arnberg; Olov Sterner; Ulf C Ellervik |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-15 |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: - ISSN: 1520-4804 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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