Document Detail


Molecular weight of guar gum affects short-chain fatty acid profile in model intestinal fermentation.
MedLine Citation:
PMID:  16967518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary fiber exerts many beneficial physiological effects; however, not all types of dietary fiber display the same effects. Partially hydrolyzed guar gum (PHGG), a lower molecular weight form of guar gum, is more easily incorporated into food, but may have less pronounced physiological effects than the native form. The aim of this study was to identify differences in intestinal fermentability based on the molecular weight of guar gum. Guar gum of four molecular masses (15, 20, 400, and 1,100 kDa) was fermented using a batch in vitro fermentation system. Human fecal inoculum was the source of microbes. The 400-kDa fraction produced the greatest concentrations of total short-chain fatty acid (SCFA) at 8 h and the highest amounts of butyrate at 24 h. At 24 h, the 400-kDa fraction produced more total SCFA and propionate than the 15 kDa, but was not different than 20 kDa or 1,100 kDa fractions. The molecular weight of guar gum was positively correlated with acetate production and negatively correlated with propionate production. This study concludes that 400-kDa guar gum may be optimal for intestinal fermentability. In conclusion, the molecular weight of guar gum affects in vitro fermentability and should be considered when adding to a food or beverage.
Authors:
Maria L Stewart; Joanne L Slavin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  50     ISSN:  1613-4125     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-04     Completed Date:  2006-11-22     Revised Date:  2007-03-22    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  971-6     Citation Subset:  IM    
Affiliation:
University of Minnesota, St. Paul, USA.
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MeSH Terms
Descriptor/Qualifier:
Acetic Acid / analysis,  metabolism
Butyrates / analysis,  metabolism
Dietary Fiber / analysis
Fatty Acids / analysis*,  biosynthesis
Feces / microbiology
Fermentation*
Galactans / chemistry*,  metabolism*
Humans
Intestines / microbiology*
Kinetics
Mannans / chemistry*,  metabolism*
Models, Biological
Molecular Weight
Plant Gums / chemistry*,  metabolism*
Propionic Acids / analysis,  metabolism
Chemical
Reg. No./Substance:
0/Butyrates; 0/Fatty Acids; 0/Galactans; 0/Mannans; 0/Plant Gums; 0/Propionic Acids; 64-19-7/Acetic Acid; 79-09-4/propionic acid; 9000-30-0/guar gum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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