| Molecular weight dependence of permselectivity to rat small intestinal blood-lymph barrier for exogenous macromolecules absorbed from lumen. | |
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MedLine Citation:
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PMID: 6202865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The permselectivity to the small intestinal blood-lymph barrier for the exogenous macromolecules absorbed from the lumen was investigated using in situ rat closed loop experiment. We chose the fluorescein isothiocyanate-labelled dextran (FD) as macromolecule and lipid-surfactant mixed micelles as an absorption promoter. The mean molecular weights of FDs used were 10500, 17500, 39000 and 64200 (abbreviated: FD10 , 20, 40 and 70). The lymph/plasma ratios of FDs concentrations during 5 h post administration were 0.2-1.2 ( FD10 ), 0.4-1.3 ( FD20 ), 1.3-7.2 ( FD40 ) and 2.6-11.9 ( FD70 ), respectively. The FD40 and FD70 levels in the lymph were significantly higher than those in the plasma. The cumulative amounts (% of the absorbed quantity) of FDs in the lymph from the lumen of the small intestine for 5 h after administration were 0.46% ( FD10 ), 0.51% ( FD20 ), 1.17% ( FD40 ) and 1.89% ( FD70 ), respectively. These findings suggest that the threshold molecular weight of FD for the transfer into the lymphatics with higher level compared to the blood concentration from the lumen across the small intestinal blood-lymph barrier exists between 17500 and 39000. |
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Authors:
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H Yoshikawa; K Takada; S Muranishi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmacobio-dynamics Volume: 7 ISSN: 0386-846X ISO Abbreviation: J. Pharmacobio-dyn. Publication Date: 1984 Jan |
Date Detail:
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Created Date: 1984-07-16 Completed Date: 1984-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7901854 Medline TA: J Pharmacobiodyn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dextrans / diagnostic use Fluorescein-5-isothiocyanate* / analogs & derivatives* Fluoresceins / diagnostic use Intestinal Absorption* Intestine, Small / metabolism* Lymph / analysis Lymphatic System / metabolism* Macromolecular Substances Male Micelles Molecular Weight Permeability Plasma / analysis Rats Rats, Inbred Strains Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Fluoresceins; 0/Macromolecular Substances; 0/Micelles; 0/fluorescein isothiocyanate dextran; 3326-32-7/Fluorescein-5-isothiocyanate; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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