Document Detail


Molecular variations in the calcium-sensing receptor in relation to sodium balance and presence of hypertension in blacks and whites.
MedLine Citation:
PMID:  10912749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium (Na) excretion is to an extent tied to calcium (Ca) excretion; increases in Ca result in increased Na excretion. We hypothesized that molecular variation in the calcium-sensing receptor (CaSR), which imparts certain of the influences of extracellular Ca, might be related to differences in Na balance and blood pressure. We further hypothesized that such an influence by CaSR is more pronounced in blacks than in whites, as the hypertension in blacks appears to be more dependent on Na retention. Three common molecular variants in CaSR were studied. Two were more frequent in the whites (A986S, P < .0001, and G990R, P = .093), whereas Q1011E was more frequent in the blacks (P < .0001). Two distinctly separate groups were studied: (1) healthy schoolchildren in whom levels of the renin-aldosterone axis and blood pressure were measured, and (2) normotensive and hypertensive adults. Studies of association were made separately in the whites and the blacks. No association of any of the variants with Na balance (as estimated from renin and aldosterone levels) was observed. In the black schoolchildren, Q1011E showed a marginal association with a higher blood pressure (P = .093 for systolic and P = .025 for diastolic), a relationship that was considered to be nonsignificant after adjusting for multiple comparisons. Nor was there a significant association of the variants with presence or absence of hypertension. In summary, studies of two cohorts that included whites and blacks did not suggest that molecular variations in the CaSR influence either Na balance or blood pressure.
Authors:
J H Pratt; W T Ambrosius; M A Wagner; K Maharry
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  13     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-02     Completed Date:  2000-11-21     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  654-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Indiana University School of Medicine, and the V.A. Medical Center, Indianapolis, USA. johpratt@iupui.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Continental Ancestry Group* / genetics
Aldosterone / blood,  urine
Blood Pressure / genetics,  physiology
Blood Pressure Monitoring, Ambulatory
Calcium / metabolism*
Child
European Continental Ancestry Group* / genetics
Female
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genotype
Humans
Hypertension / ethnology,  metabolism*,  physiopathology
Indiana / epidemiology
Longitudinal Studies
Male
Middle Aged
Receptors, Calcium-Sensing
Receptors, Cell Surface / genetics*,  metabolism
Renin / blood,  urine
Sodium / metabolism*
Grant Support
ID/Acronym/Agency:
M01-RR00750/RR/NCRR NIH HHS; R01-HL-35795/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/Receptors, Calcium-Sensing; 0/Receptors, Cell Surface; 52-39-1/Aldosterone; 7440-23-5/Sodium; 7440-70-2/Calcium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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