| Molecular understanding and modern application of traditional medicines: triumphs and trials. | |
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MedLine Citation:
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PMID: 17803898 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Traditional medicines provide fertile ground for modern drug development, but first they must pass along a pathway of discovery, isolation, and mechanistic studies before eventual deployment in the clinic. Here, we highlight the challenges along this route, focusing on the compounds artemisinin, triptolide, celastrol, capsaicin, and curcumin. |
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Authors:
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Timothy W Corson; Craig M Crews |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell Volume: 130 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-06 Completed Date: 2007-10-19 Revised Date: 2010-12-17 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 769-74 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Artemisinins / pharmacology Capsaicin / pharmacology Curcumin / pharmacology Diterpenes / pharmacology Drug Approval Drug Evaluation, Preclinical Epoxy Compounds / pharmacology Humans Medicine, Traditional* Phenanthrenes / pharmacology Plant Preparations / chemistry, pharmacology*, therapeutic use Technology, Pharmaceutical Triterpenes / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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AI055194/AI/NIAID NIH HHS; GM062120/GM/NIGMS NIH HHS; R01 GM062120-11/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Artemisinins; 0/Diterpenes; 0/Epoxy Compounds; 0/Phenanthrenes; 0/Plant Preparations; 0/Triterpenes; 34157-83-0/tripterine; 38748-32-2/triptolide; 404-86-4/Capsaicin; 458-37-7/Curcumin; 63968-64-9/artemisinine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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