Document Detail


"Molecular trinity" for soft nanomaterials: Integrating nucleobases, amino acids, and glycosides to construct multifunctional hydrogelators.
MedLine Citation:
PMID:  24368929     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This highlight introduces the development of hydrogelators consisting of nucleobases, amino acids, and glycosides (i.e., molecular trinity), or nucleobases and amino acids (i.e., nucleopeptides). These novel small molecule hydrogelators self-assemble in water to form stable supramolecular nanofibers/hydrogels and exhibit useful biological properties (e.g., biocompatibility, biostability, and the ability to bind and transport DNA into live cells). The approach discussed here not only provides a new strategy to develop soft biomaterials as a form of nanomedicines, but also contributes to the understanding of molecular self-assembly in water by modulating the non-covalent interactions derived from the three basic building blocks used in living organisms.
Authors:
Xinming Li; Yi Kuang; Bing Xu
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Soft matter     Volume:  8     ISSN:  1744-683X     ISO Abbreviation:  Soft Matter     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2013-12-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101295070     Medline TA:  Soft Matter     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 CA142746/CA/NCI NIH HHS

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