Document Detail

Molecular therapeutics--lessons from the role of Src in cellular signalling.
MedLine Citation:
PMID:  16180547     Owner:  NLM     Status:  MEDLINE    
Src is the oldest and best studied protooncogene participating in normal cells in proliferation, maintenance of normal intercellular contacts and cell motility. Its discovery opened the way for fundamental discoveries on the cell cycle, cell growth and death, cell-cell signalling, cell morphology and motility, and cancer biology. Src is poorly transforming, consistent with a role as a normal cellular protooncogene that, when activated, might serve as an oncogene. Its activation promotes growth during the process of tumorigenesis by stimulating the proliferation of pre-cancerous cells and also regulates other activities such as adhesion and invasion during the later stages of tumour progression. Overexpression of the Src protein and the increase of its specific protein kinase activity have been observed in various human malignancies and linked to the development of cancer and tumour progression to distant metastases. These observations have led to the recent rediscovery of Src, a molecule that has been investigated during nearly a century and that shows promise as a new target for therapy of human cancer in the development of anticancer therapeutics. To determine the role of Src in human cancer, which is still not fully understood, molecular details of many pathways that intersect with Src are necessary to be uncovered. A detailed map of signalling pathways regulating signal transduction and signal integration induced by Src may identify location of different "checkpoints" for the therapeutic intervention of human diseases due to the altered activity of Src.
Z Tuhácková
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Folia biologica     Volume:  51     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  2005  
Date Detail:
Created Date:  2005-09-26     Completed Date:  2005-11-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  114-20     Citation Subset:  IM    
Department of Intracellular Communications, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
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MeSH Terms
Drug Design
Models, Molecular
Neoplasms / drug therapy*,  etiology,  pathology
Signal Transduction*
src-Family Kinases / antagonists & inhibitors,  physiology*
Reg. No./Substance:
EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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