| Molecular symmetry in mitochondrial cardiolipins. | |
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MedLine Citation:
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PMID: 16226238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiolipin is a unique mitochondrial phospholipid with an atypical fatty acid profile, but the significance of its acyl specificity has not been understood. We explored the enormous combinatorial diversity among cardiolipin species, which results from the presence of four fatty acids in each molecule, by integrated use of high-performance liquid chromatography, mass spectrometry, diacylglycerol species analysis, fatty acid analysis, and selective cleavage of fatty acids by phospholipase A2. The most abundant cardiolipin species from various organisms and tissues (human heart, human lymphoblasts, rat liver, Drosophila, sea urchin sperm, yeast, mung bean hypocotyls) contained only one or two types of fatty acids, which generated a high degree of structural uniformity and molecular symmetry. However, an exception was found in patients with Barth syndrome, in whom an acyltransferase deficiency led to loss of acyl selectivity and formation of multiple molecular species. These results suggest that restriction of the number of fatty acid species, rather than the selection of a particular kind of fatty acid, is the common theme of eukaryotic cardiolipins. This limits the structural diversity of the cardiolipin species and creates molecular symmetry with implications for the stereochemistry of cardiolipin. |
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Authors:
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Michael Schlame; Mindong Ren; Yang Xu; Miriam L Greenberg; Ivan Haller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-07 |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 138 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-08 Completed Date: 2006-02-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: Ireland |
Other Details:
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Languages: eng Pagination: 38-49 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA. michael.schlame@med.nyu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acyltransferases
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deficiency Adolescent Adult Animals Cardiolipins / chemistry* Child Child, Preschool Chromatography, High Pressure Liquid Drosophila melanogaster Fatty Acids / chemistry Humans Infant Mitochondria / chemistry* Organ Specificity Phaseolus Phospholipases A / chemistry Phospholipases A2 Rats Saccharomyces cerevisiae Sea Urchins Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Fatty Acids; EC 2.3.-/Acyltransferases; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
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