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Molecular and structural antioxidant defences against oxidative stress in animals.
MedLine Citation:
PMID:  21775650     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this review, it is our aim (1) to describe the high diversity in molecular and structural antioxidant defences against oxidative stress in animals, (2) to extend the traditional concept of antioxidant to other structural and functional factors affecting the 'whole' organism, (3) to incorporate, when supportable by evidence, mechanisms into models of life-history trade-offs and maternal/epigenetic inheritance, (4) to highlight the importance of studying the biochemical integration of redox systems, and (5) to discuss the link between maximum life span and antioxidant defences. The traditional concept of antioxidant emphasises the importance of the chemical nature of molecules with antioxidant properties. Research in the last 20 years shows that animals have also evolved a high diversity in structural defences that should be incorporated in research on antioxidant responses to reactive species. Although a high diversity in antioxidant defences, many of them are evolutionary conserved across animal taxa. In particular, enzymatic defences and heat shock response mediated by proteins show a low degree of variation. Importantly activation of an antioxidant response may be also energetically and nutrient demanding. So the knowledge of antioxidant mechanisms can allow to indentify and to quantify any underlying costs, which can help explain life-history trade-offs. Moreover, the study of inheritance mechanisms of antioxidant mechanisms has clear potential to evaluate the contribution of epigenetic mechanisms to stress response phenotype variation.
Authors:
Reinald Pamplona; David Costantini
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-20
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  -     ISSN:  1522-1490     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1University of Lleida-IRBLLEIDA.
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