| Molecular species of phosphoglycerides in liver microsomes of rats fed a fat-free diet. | |
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MedLine Citation:
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PMID: 9168457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of a fat-free diet on the molecular species composition of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) of rat liver microsomes was studied by using reversed-phase high-pressure liquid chromatography. In the three phosphoglyceride classes analyzed, the fat-free diet produced a large decrease in the 18:0/20:4n-6 species but less important changes were found in the 16:0/20:4n-6 species. In PC, the most abundant phosphoglyceride class of rat liver microsomes, the fall in the 18:0/20:4n-6 species was counterbalanced mainly by an enhancement in the 16:0/18:1n-9 species although it was not evident in PE. In PI, the decrease in the 18:0/20:4n-6 species was counterbalanced by an increase in the 18:0/20:3n-9 species. Fluorescence polarization measurements of 1,7-diphenyl-1,3,5-hexatriene in liposomes of 16:0/18:1n-9, 18:0/18:1n-9-, 16:0/20:4n-6-, and 18:0/20:4n-6-PC indicated that the change in the saturated fatty acid in the sn-1 position accompanying the replacement of 20:4n-6 by 18:1n-9 could be very important for a homeoviscous compensation, maintaining the membrane physical properties without large alterations in spite of the essential fatty acid deficiency due to the fat-free diet. |
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Authors:
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H A Garda; A M Bernasconi; M A Tricerri; R R Brenner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lipids Volume: 32 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-08-04 Completed Date: 1997-08-04 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 507-13 Citation Subset: IM |
Affiliation:
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Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), CONICET-UNLP, Facultad de Ciencias Médicas, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid Diet, Fat-Restricted* Fatty Acids / analysis* Fatty Acids, Unsaturated / analysis Fluorescence Polarization Liposomes Male Microsomes, Liver / chemistry* Phosphatidylcholines / analysis, chemistry* Phosphatidylethanolamines / analysis, chemistry* Phosphatidylinositols / analysis, chemistry* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Liposomes; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phosphatidylinositols |
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