Document Detail

Molecular species of phosphoglycerides in liver microsomes of rats fed a fat-free diet.
MedLine Citation:
PMID:  9168457     Owner:  NLM     Status:  MEDLINE    
The influence of a fat-free diet on the molecular species composition of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) of rat liver microsomes was studied by using reversed-phase high-pressure liquid chromatography. In the three phosphoglyceride classes analyzed, the fat-free diet produced a large decrease in the 18:0/20:4n-6 species but less important changes were found in the 16:0/20:4n-6 species. In PC, the most abundant phosphoglyceride class of rat liver microsomes, the fall in the 18:0/20:4n-6 species was counterbalanced mainly by an enhancement in the 16:0/18:1n-9 species although it was not evident in PE. In PI, the decrease in the 18:0/20:4n-6 species was counterbalanced by an increase in the 18:0/20:3n-9 species. Fluorescence polarization measurements of 1,7-diphenyl-1,3,5-hexatriene in liposomes of 16:0/18:1n-9, 18:0/18:1n-9-, 16:0/20:4n-6-, and 18:0/20:4n-6-PC indicated that the change in the saturated fatty acid in the sn-1 position accompanying the replacement of 20:4n-6 by 18:1n-9 could be very important for a homeoviscous compensation, maintaining the membrane physical properties without large alterations in spite of the essential fatty acid deficiency due to the fat-free diet.
H A Garda; A M Bernasconi; M A Tricerri; R R Brenner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lipids     Volume:  32     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-08-04     Completed Date:  1997-08-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-13     Citation Subset:  IM    
Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), CONICET-UNLP, Facultad de Ciencias Médicas, Argentina.
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MeSH Terms
Chromatography, High Pressure Liquid
Diet, Fat-Restricted*
Fatty Acids / analysis*
Fatty Acids, Unsaturated / analysis
Fluorescence Polarization
Microsomes, Liver / chemistry*
Phosphatidylcholines / analysis,  chemistry*
Phosphatidylethanolamines / analysis,  chemistry*
Phosphatidylinositols / analysis,  chemistry*
Rats, Wistar
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Liposomes; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines; 0/Phosphatidylinositols

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