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Molecular signatures of end-stage heart failure.
MedLine Citation:
PMID:  21962426     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: To date, gene expression studies related to chronic heart failure (CHF) have mainly involved microarray analysis of myocardial tissues. The potential utility of blood to infer the etiology, pathogenesis, and course of CHF remains unclear. Further, the use of proteomic and metabolomic platforms for molecular profiling of CHF is relatively unexplored.
METHODS: Microarray genomic, iTRAQ proteomic, and nuclear magnetic resonance metabolomic analyses were carried out on blood samples from 29 end-stage CHF patients (16 ischemic heart disease [IHD], 13 nonischemic cardiomyopathy [NICM]), and 20 normal cardiac function (NCF) controls. Robust statistical tests and bioinformatical tools were applied to identify and compare the molecular signatures among these subject groups.
RESULTS: No genes or proteins, and only two metabolites, were differentially expressed between IHD and NICM patients at end stage. However, CHF versus NCF comparison revealed differential expression of 7,426 probe sets, 71 proteins, and 8 metabolites. Functional enrichment analyses of the CHF versus NCF results revealed several in-common biological themes and potential mechanisms underlying advanced heart failure.
CONCLUSION: Multiple "-omic" analyses support the convergence of dramatic changes in molecular processes underlying IHD and NICM at end stage.
David Lin; Zsuzsanna Hollander; Anna Meredith; Ellamae Stadnick; Mayu Sasaki; Gabriela Cohen Freue; Pooran Qasimi; Alice Mui; Raymond T Ng; Robert Balshaw; Janet E Wilson-McManus; David Wishart; David Hau; Paul A Keown; Robert McMaster; Bruce M McManus;
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Publication Detail:
Type:  Journal Article     Date:  2011-09-03
Journal Detail:
Title:  Journal of cardiac failure     Volume:  17     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  867-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada; The NCE CECR PROOF Centre of Excellence, Vancouver, British Columbia, Canada.
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