Document Detail

Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells.
MedLine Citation:
PMID:  20238234     Owner:  NLM     Status:  MEDLINE    
The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows polarized, well-differentiated epithelial cells to convert to unpolarized, motile mesenchymal cells. EMT is critical for appropriate embryogenesis and plays a crucial role in tumorigenesis and cancer progression. Recent studies revealed that there is a direct link between the EMT program and the gain of epithelial stem cell properties. EMT is sufficient to induce a population with stem cell characteristics from well-differentiated epithelial cells and cancer cells. In this review, we briefly introduce the biology of EMT inducers and transcription factors in tumorigenesis and then focus on the role of these key players of the EMT in generating and maintaining cancer stem cells.
Gaoliang Ouyang; Zhe Wang; Xiaoguang Fang; Jia Liu; Chaoyong James Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-03-18
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  67     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-24     Completed Date:  2010-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2605-18     Citation Subset:  IM    
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, China.
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MeSH Terms
Cell Dedifferentiation
Cell Differentiation / genetics
Embryonic Development / genetics
Epithelial Cells / metabolism*
Mesenchymal Stem Cells / metabolism
Neoplasms / genetics
Neoplastic Stem Cells / metabolism
Signal Transduction / genetics*
Stem Cells / metabolism
Transcription Factors / genetics
Reg. No./Substance:
0/Transcription Factors

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