| Molecular seismology: an inverse problem in nanobiology. | |
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MedLine Citation:
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PMID: 17275035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The density profile of an elastic fiber like DNA will change in space and time as ligands associate with it. This observation affords a new direction in single molecule studies provided that density profiles can be measured in space and time. In fact, this is precisely the objective of seismology, where the mathematics of inverse problems have been employed with success. We argue that inverse problems in elastic media can be directly applied to biophysical problems of fiber-ligand association, and demonstrate that robust algorithms exist to perform density reconstruction in the condensed phase. |
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Authors:
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Peter Hinow; Erik M Boczko |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-11-29 |
Journal Detail:
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Title: Journal of theoretical biology Volume: 246 ISSN: 0022-5193 ISO Abbreviation: J. Theor. Biol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-13 Completed Date: 2007-06-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 145-58 Citation Subset: IM |
Affiliation:
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Department of Mathematics, Vanderbilt University, Nashville, TN 37240, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Animals Computer Simulation* DNA / metabolism* Elasticity Hot Temperature Ligands Models, Genetic* Molecular Conformation Protein Binding Signal Transduction / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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1-P50-CA1137007-02/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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