| Molecular screening of interleukin-6 gene promoter and influence of -174G/C polymorphism on breast cancer. | |
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MedLine Citation:
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PMID: 19640729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including carcinogenesis. In 2003, a single nucleotide polymorphism (-174G/C) of the IL-6 gene promoter has been linked to breast cancer prognosis in node-positive (N+) breast cancer patients. Since, different studies have led to conflicting conclusions about its role as a prognostic and/or diagnostic marker. The primary aim of our study was to investigate the link between -174G/C polymorphism and breast cancer risk on the one hand, and -174G/C polymorphism and prognosis in different groups of patients: sporadic N+breast cancers (n=138), sporadic N- breast cancers (n=95) and familial breast cancer (n=60) on the other hand. The variables of interest were disease-free survival and overall survival. The secondary aim of the study was to screen IL-6 gene promoter using direct sequencing to identify new polymorphisms in our French Caucasian breast cancer population. No association or trend of association between -174G/C polymorphism of IL-6 gene promoter gene and breast cancer diagnosis or prognosis was shown, even in meta-analyses. Furthermore, we have identified four novel polymorphic sites in the IL-6 gene promoter region: -764G-->A, -757C-->T, -233T-->A, 15C-->A. |
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Authors:
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Michel Chérel; Loïc Campion; Stéphane Bézieau; Mario Campone; Josiane Charrier; Joëlle Gaschet; Gabriel Ricolleau; Wilfried Gouraud; Catherine Charbonnel; Pascal Jézéquel |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't Date: 2009-07-28 |
Journal Detail:
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Title: Cytokine Volume: 47 ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2009-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9005353 Medline TA: Cytokine Country: United States |
Other Details:
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Languages: eng Pagination: 214-23 Citation Subset: IM |
Affiliation:
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Département de Recherche en Cancérologie, Université de Nantes, INSERM U892, 9 quai Moncousu, 44035 Nantes Cedex, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Base Sequence Breast Neoplasms / diagnosis, genetics*, mortality Disease-Free Survival Female Gene Frequency Genetic Markers Humans Interleukin-6 / genetics* Middle Aged Molecular Sequence Data Polymorphism, Single Nucleotide* Prognosis Promoter Regions, Genetic* Sequence Analysis, DNA |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers; 0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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