Document Detail


Molecular screening of interleukin-6 gene promoter and influence of -174G/C polymorphism on breast cancer.
MedLine Citation:
PMID:  19640729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including carcinogenesis. In 2003, a single nucleotide polymorphism (-174G/C) of the IL-6 gene promoter has been linked to breast cancer prognosis in node-positive (N+) breast cancer patients. Since, different studies have led to conflicting conclusions about its role as a prognostic and/or diagnostic marker. The primary aim of our study was to investigate the link between -174G/C polymorphism and breast cancer risk on the one hand, and -174G/C polymorphism and prognosis in different groups of patients: sporadic N+breast cancers (n=138), sporadic N- breast cancers (n=95) and familial breast cancer (n=60) on the other hand. The variables of interest were disease-free survival and overall survival. The secondary aim of the study was to screen IL-6 gene promoter using direct sequencing to identify new polymorphisms in our French Caucasian breast cancer population. No association or trend of association between -174G/C polymorphism of IL-6 gene promoter gene and breast cancer diagnosis or prognosis was shown, even in meta-analyses. Furthermore, we have identified four novel polymorphic sites in the IL-6 gene promoter region: -764G-->A, -757C-->T, -233T-->A, 15C-->A.
Authors:
Michel Chérel; Loïc Campion; Stéphane Bézieau; Mario Campone; Josiane Charrier; Joëlle Gaschet; Gabriel Ricolleau; Wilfried Gouraud; Catherine Charbonnel; Pascal Jézéquel
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2009-07-28
Journal Detail:
Title:  Cytokine     Volume:  47     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-23     Citation Subset:  IM    
Affiliation:
Département de Recherche en Cancérologie, Université de Nantes, INSERM U892, 9 quai Moncousu, 44035 Nantes Cedex, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Base Sequence
Breast Neoplasms / diagnosis,  genetics*,  mortality
Disease-Free Survival
Female
Gene Frequency
Genetic Markers
Humans
Interleukin-6 / genetics*
Middle Aged
Molecular Sequence Data
Polymorphism, Single Nucleotide*
Prognosis
Promoter Regions, Genetic*
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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