Document Detail

Molecular screening of interleukin-6 gene promoter and influence of -174G/C polymorphism on breast cancer.
MedLine Citation:
PMID:  19640729     Owner:  NLM     Status:  MEDLINE    
Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including carcinogenesis. In 2003, a single nucleotide polymorphism (-174G/C) of the IL-6 gene promoter has been linked to breast cancer prognosis in node-positive (N+) breast cancer patients. Since, different studies have led to conflicting conclusions about its role as a prognostic and/or diagnostic marker. The primary aim of our study was to investigate the link between -174G/C polymorphism and breast cancer risk on the one hand, and -174G/C polymorphism and prognosis in different groups of patients: sporadic N+breast cancers (n=138), sporadic N- breast cancers (n=95) and familial breast cancer (n=60) on the other hand. The variables of interest were disease-free survival and overall survival. The secondary aim of the study was to screen IL-6 gene promoter using direct sequencing to identify new polymorphisms in our French Caucasian breast cancer population. No association or trend of association between -174G/C polymorphism of IL-6 gene promoter gene and breast cancer diagnosis or prognosis was shown, even in meta-analyses. Furthermore, we have identified four novel polymorphic sites in the IL-6 gene promoter region: -764G-->A, -757C-->T, -233T-->A, 15C-->A.
Michel Chérel; Loïc Campion; Stéphane Bézieau; Mario Campone; Josiane Charrier; Joëlle Gaschet; Gabriel Ricolleau; Wilfried Gouraud; Catherine Charbonnel; Pascal Jézéquel
Related Documents :
16758119 - Interaction of genetic polymorphisms in cytochrome p450 2e1 and glutathione s-transfera...
10744039 - Lack of evidence of association of p21waf1/cip1 polymorphism with lung cancer susceptib...
15065089 - Vitamin d receptor gene polymorphisms and prostate cancer risk.
20076999 - No association between a progesterone receptor gene promoter polymorphism (+331g>a) and...
17187359 - Variant alleles of tgfb1 and tgfbr2 are associated with a decreased risk of gastric can...
15942659 - A polymorphism at codon 133 of the tumor suppressor rassf1a is associated with tumorous...
7532929 - Significance of the tumour markers ca 125 ii, ca 72-4, casa and cyfra 21-1 in ovarian c...
20027689 - Carcinoma of the papilla of vater following treatment of pancreaticobiliary maljunction.
9400709 - Asbestos, asbestosis, and lung cancer: observations in quebec chrysotile workers.
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2009-07-28
Journal Detail:
Title:  Cytokine     Volume:  47     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-23     Citation Subset:  IM    
Département de Recherche en Cancérologie, Université de Nantes, INSERM U892, 9 quai Moncousu, 44035 Nantes Cedex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Base Sequence
Breast Neoplasms / diagnosis,  genetics*,  mortality
Disease-Free Survival
Gene Frequency
Genetic Markers
Interleukin-6 / genetics*
Middle Aged
Molecular Sequence Data
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic*
Sequence Analysis, DNA
Reg. No./Substance:
0/Genetic Markers; 0/Interleukin-6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Surgical treatment of prosthetic valve endocarditis in patients with double prostheses: is single-va...
Next Document:  Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumo...