| Molecular regulators of pubertal mammary gland development. | |
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MedLine Citation:
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PMID: 21417804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract The pubertal mammary gland is an ideal model for experimental morphogenesis. The primary glandular branching morphogenesis occurs at this time, integrating epithelial cell proliferation, differentiation, and apoptosis. Between birth and puberty, the mammary gland exists in a relatively quiescent state. At the onset of puberty, rapid expansion of a pre-existing rudimentary mammary epithelium generates an extensive ductal network by a process of branch initiation, elongation, and invasion of the mammary mesenchyme. It is this branching morphogenesis that characterizes pubertal mammary gland growth. Tissue-specific molecular networks interpret signals from local cytokines/growth factors in both the epithelial and stromal microenvironments. This is largely orchestrated by secreted ovarian and pituitary hormones. Here, we review the major molecular regulators of pubertal mammary gland development. |
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Authors:
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Sara McNally; Finian Martin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-20 |
Journal Detail:
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Title: Annals of medicine Volume: - ISSN: 1365-2060 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8906388 Medline TA: Ann Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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UCD School of Bimolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Ireland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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