Document Detail

Molecular regulation of Na+-K+-2Cl- cotransporter (NKCC1) and epithelial chloride secretion.
MedLine Citation:
PMID:  11948363     Owner:  NLM     Status:  MEDLINE    
Defective regulation of epithelial secretion underlies the clinical manifestations of a number of important human diseases ranging from cystic fibrosis to secretory diarrhea. Although much attention has focused on the role of apical membrane chloride (Cl-) channels in this process, emerging evidence highlights the importance of a basolateral Na+-K+-2Cl- cotransporter (NKCC1) as an independent regulatory site that may determine the overall rate of epithelial secretion. The cotransporter NKCC1 is expressed not only in epithelial cells but also in virtually all mammalian cells, where it plays a more generalized role in cell volume homeostasis, cell ionic composition, and, possibly, the control of cell growth. Emerging molecular evidence indicates that NKCC1 function is regulated in the short and long term at the level of protein phosphorylation, membrane targeting, and gene expression. An improved understanding of NKCC1 may lead to new therapeutic approaches to secretory diarrhea as well as diverse clinical conditions in which cell ion composition is disturbed.
Jeffrey B Matthews
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2002-04-15
Journal Detail:
Title:  World journal of surgery     Volume:  26     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-03     Completed Date:  2002-09-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  826-30     Citation Subset:  IM    
Division of General and Gastrointestinal Surgery, Stoneman 928, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
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MeSH Terms
Chlorides / physiology*
Epithelial Cells / physiology*
Sodium-Potassium-Chloride Symporters / genetics*,  metabolism*
Grant Support
Reg. No./Substance:
0/Chlorides; 0/Sodium-Potassium-Chloride Symporters; 0/sodium-potassium-chloride cotransporter 1 protein

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