| Molecular recognition of nitrated fatty acids by PPAR gamma. | |
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MedLine Citation:
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PMID: 18604218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peroxisome proliferator activated receptor-gamma (PPAR gamma) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPAR gamma ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPAR gamma. Structural and functional studies of receptor-ligand interactions reveal the molecular basis of PPAR gamma discrimination of various naturally occurring fatty acid derivatives. |
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Authors:
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Yong Li; Jifeng Zhang; Francisco J Schopfer; Dariusz Martynowski; Minerva T Garcia-Barrio; Amanda Kovach; Kelly Suino-Powell; Paul R S Baker; Bruce A Freeman; Y Eugene Chen; H Eric Xu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-07-06 |
Journal Detail:
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Title: Nature structural & molecular biology Volume: 15 ISSN: 1545-9985 ISO Abbreviation: Nat. Struct. Mol. Biol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-05 Completed Date: 2008-09-02 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 101186374 Medline TA: Nat Struct Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 865-7 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, Center for Pharmacogenetics, 709 Salk Hall, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. yol21@pitt.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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PDB/3CWD |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipocytes
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cytology Cell Differentiation Crystallography, X-Ray / methods Fatty Acids / chemistry* Humans Ligands Linoleic Acid / chemistry Models, Molecular Molecular Conformation Nitrogen / chemistry Oxygen / chemistry PPAR gamma / chemistry, metabolism* Protein Structure, Tertiary |
| Grant Support | |
ID/Acronym/Agency:
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DK066202/DK/NIDDK NIH HHS; DK071662/DK/NIDDK NIH HHS; HL089301/HL/NHLBI NIH HHS; HL089544/HL/NHLBI NIH HHS; HL58115/HL/NHLBI NIH HHS; HL64937/HL/NHLBI NIH HHS; HL68878/HL/NHLBI NIH HHS; HL75397/HL/NHLBI NIH HHS; R01 HL089301-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Ligands; 0/PPAR gamma; 2197-37-7/Linoleic Acid; 7727-37-9/Nitrogen; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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