| Molecular recognition by Kluyveromyces of amphotericin B-loaded, galactose-tagged, poly (lactic acid) microspheres. | |
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MedLine Citation:
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PMID: 11937335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an effort to develop a new way of drug delivery, especially for polyenic antifungal molecules, we have incorporated amphotericin B (AmB) into biodegradable galactosylated poly (L-lactic acid) (L-PLA) and poly (L-lactic-co-glycolic acid) (PLGA) microspheres. These drug carriers were prepared by solvent evaporation using an oil/water (o/w) emulsion. The ratio of galactosyl spacers with different chain lengths was 1.74-2.78%. The maximal quantity of AmB encapsulated reported to 100 mg of the galactosylated microspheres was 7.14 mg for L-PLA (encapsulation rate 45% of mole) and 6.42 mg for PLGA derivatives (encapsulation rate 81% of mole). In our yeast model, drug release depended on three factors: (i) presence of galactosylated antennae, (ii) length of galactosyl antenna and (iii) nature of the polymer. More of the AmB trapped in PLGA microspheres was released than from PLA microspheres. These novel functionalised microspheres could be required for the delivering of therapeutic agents according to their recognition to specific cells. |
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Authors:
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Rima Kassab; Hélène Parrot-Lopez; Hatem Fessi; Jean Menaucourt; Roger Bonaly; Joël Coulon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: 10 ISSN: 0968-0896 ISO Abbreviation: Bioorg. Med. Chem. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-04-08 Completed Date: 2003-02-10 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: England |
Other Details:
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Languages: eng Pagination: 1767-75 Citation Subset: IM |
Affiliation:
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UMR 5078 CNRS, Université Claude Bernard, Bât. 305, 43 bd du 11 Novembre 1918, 69622, Villeurbanne Cedex, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amphotericin B
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administration & dosage*,
pharmacology Antifungal Agents / administration & dosage*, pharmacology Drug Carriers / chemical synthesis*, chemistry* Galactose / chemistry* Glycolates / chemistry* Kluyveromyces / drug effects, growth & development, physiology* Logistic Models Microscopy, Atomic Force Microspheres Molecular Structure Molecular Weight Polymers / chemistry Substrate Specificity |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Drug Carriers; 0/Glycolates; 0/Polymers; 0/polylactic acid-polyglycolic acid copolymer; 1397-89-3/Amphotericin B; 26566-61-0/Galactose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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