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Molecular properties of hybrid macromolecular antioxidants: Dextran hydrophobically modified by sterically hindered phenols.
MedLine Citation:
PMID:  22105139     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity -polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule. An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure.
Authors:
S K Filippov; B Porsch; O Yu Sergeeva; A S Olifirenko; S B Lesnichin; N S Domnina; E A Komarova; A V Lezov; V M Garamus; Z Walterova; P Stepanek
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Publication Detail:
Type:  Journal Article     Date:  2011-11-23
Journal Detail:
Title:  The European physical journal. E, Soft matter     Volume:  34     ISSN:  1292-895X     ISO Abbreviation:  Eur Phys J E Soft Matter     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126530     Medline TA:  Eur Phys J E Soft Matter     Country:  France    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Affiliation:
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i. Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic, filippov@imc.cas.cz.
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