| Molecular properties of hybrid macromolecular antioxidants: Dextran hydrophobically modified by sterically hindered phenols. | |
MedLine Citation:
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PMID: 22105139 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity -polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule. An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure. |
Authors:
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S K Filippov; B Porsch; O Yu Sergeeva; A S Olifirenko; S B Lesnichin; N S Domnina; E A Komarova; A V Lezov; V M Garamus; Z Walterova; P Stepanek |
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Publication Detail:
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Type: Journal Article Date: 2011-11-23 |
Journal Detail:
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Title: The European physical journal. E, Soft matter Volume: 34 ISSN: 1292-895X ISO Abbreviation: Eur Phys J E Soft Matter Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101126530 Medline TA: Eur Phys J E Soft Matter Country: France |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Affiliation:
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Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i. Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic, filippov@imc.cas.cz. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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