Document Detail

Molecular profiling of multiple myeloma: from gene expression analysis to next-generation sequencing.
MedLine Citation:
PMID:  23614397     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Multiple myeloma is a fatal malignant proliferation of clonal bone marrow Ig-secreting plasma cells, characterized by wide clinical, biological, and molecular heterogeneity.
AREAS COVERED: Herein, global gene and microRNA expression, genome-wide DNA profilings, and next-generation sequencing technology used to investigate the genomic alterations underlying the bio-clinical heterogeneity in multiple myeloma are discussed.
EXPERT OPINION: High-throughput technologies have undoubtedly allowed a better comprehension of the molecular basis of the disease, a fine stratification, and early identification of high-risk patients, and have provided insights toward targeted therapy studies. However, such technologies are at risk of being affected by laboratory- or cohort-specific biases, and are moreover influenced by high number of expected false positives. This aspect has a major weight in myeloma, which is characterized by large molecular heterogeneity. Therefore, meta-analysis as well as multiple approaches are desirable if not mandatory to validate the results obtained, in line with commonly accepted recommendation for tumor diagnostic/prognostic biomarker studies.
Luca Agnelli; Pierfrancesco Tassone; Antonino Neri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-04-24
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  13 Suppl 1     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-24     Completed Date:  2014-01-22     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  S55-68     Citation Subset:  IM    
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MeSH Terms
Gene Expression Profiling*
Gene Expression Regulation, Neoplastic*
High-Throughput Nucleotide Sequencing*
Multiple Myeloma / diagnosis,  genetics*,  therapy
Tumor Markers, Biological / genetics*
Reg. No./Substance:
0/Tumor Markers, Biological

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