Document Detail


Molecular profiles: a new tool to substantiate serum banks for evaluation of potential allergenicity of GMO.
MedLine Citation:
PMID:  18706962     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Assessment of the allergenicity of GMOs involves performing a test with a panel of sera obtained from allergic donors. However, there is no clear indication of how to characterize the above-mentioned panel. The patient selection criteria should take into account the geographical location of patients, the intensity and nature of the environmental allergens in the area and the potential cross-reactivity among allergenic molecules. Sera for serum banks, obtained from patients with demonstrated food allergy, should be subjected to a further characterization by screening with a panel of relevant allergenic molecules. A representative panel of these sera should be used in the allergenicity assessment. Finally, the "in vitro" methodologies should have the adequate specificity and sensitivity, and the integrity of the molecules tested should be guaranteed.
Authors:
D Barber; R Rodríguez; G Salcedo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-30
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46 Suppl 10     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2009-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  S35-40     Citation Subset:  IM    
Affiliation:
Departamento de I+D, ALK-Abelló S.A., C/Miguel Fleta 19, E-28037 Madrid, Spain. domingo.barber@alk-abello.com
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MeSH Terms
Descriptor/Qualifier:
Allergens / analysis,  immunology*
Antibody Specificity
Food Hypersensitivity / diagnosis*,  immunology
Food, Genetically Modified
Humans
Immune Sera / immunology*
Immunoglobulin E / immunology
Plants, Genetically Modified / immunology*
Rhinitis, Allergic, Seasonal / diagnosis*,  immunology
Chemical
Reg. No./Substance:
0/Allergens; 0/Immune Sera; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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