Document Detail


Molecular probes for imaging myelinated white matter in CNS.
MedLine Citation:
PMID:  18844339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abnormalities and changes in myelination in the brain are seen in many neurodegenerative disorders such as multiple sclerosis (MS). Direct detection and quantification of myelin content in vivo is desired to facilitate diagnosis and therapeutic treatments of myelin-related diseases. The imaging studies require use of myelin-imaging agents that readily enter the brain and selectively bind to myelinated regions. For this purpose, we have systematically evaluated a series of stilbene derivatives as myelin imaging agents. Spectrophotometry-based and radioligand-based binding assays showed that these stilbene derivatives exhibited relatively high myelin-binding affinities. In vitro myelin staining exhibited that the compounds selectively stained intact myelinated regions in wild type mouse brain. In situ tissue staining demonstrated that the compounds readily entered the mouse brain and selectively labeled myelinated white matter regions. These studies suggested that these stilbene derivatives can be used as myelin-imaging probes to monitor myelin pathology in vivo.
Authors:
Chunying Wu; Jinjun Wei; Donghua Tian; Yue Feng; Robert H Miller; Yanming Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-10-10
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  51     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-07     Completed Date:  2008-11-28     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6682-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Blood-Brain Barrier / metabolism
Brain / metabolism
Central Nervous System / chemistry*,  metabolism*
Mice
Molecular Probes / analysis*,  chemical synthesis,  chemistry*,  metabolism
Molecular Structure
Myelin Sheath / metabolism*
Radioligand Assay
Spectrophotometry
Grant Support
ID/Acronym/Agency:
NS054109/NS/NINDS NIH HHS; NS061837/NS/NINDS NIH HHS; NS30800/NS/NINDS NIH HHS; R01 NS061837/NS/NINDS NIH HHS; R01 NS061837-01A1/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Molecular Probes
Comments/Corrections

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