Document Detail

Molecular physiology of the WNK kinases.
MedLine Citation:
PMID:  17961084     Owner:  NLM     Status:  MEDLINE    
Mutations in the serine-threonine kinases WNK1 and WNK4 cause a Mendelian disease featuring hypertension and hyperkalemia. In vitro and in vivo studies have revealed that these proteins are molecular switches that have discrete functional states that impart different effects on downstream ion channels, transporters, and the paracellular pathway. These effects enable the distal nephron to allow either maximal NaCl reabsorption or maximal K+ secretion in response to hypovolemia or hyperkalemia, respectively. The related kinase WNK3 has reciprocal actions on the primary mediators of cellular Cl(-) influx and efflux, effects that can serve to regulate cell volume during growth and in response to osmotic stress as well as to modulate neuronal responses to GABA. These findings define a versatile new family of kinases that coordinate the activities of diverse ion transport pathways to achieve and maintain fluid and electrolyte homeostasis.
Kristopher T Kahle; Aaron M Ring; Richard P Lifton
Related Documents :
11361144 - Phosphorylation of the catalytic subunit of rat renal na+, k+-atpase by classical pkc i...
2166534 - Short-term regulation of na+,k(+)-atpase activity by dopamine.
9374654 - The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells.
7559664 - Involvement of direct phosphorylation in the regulation of the rat parotid na(+)-k(+)-2...
7978284 - Use of a synthetic peptide as a selective substrate for glycogen synthase kinase 3.
11741914 - Molecular characterization of ancylostoma inhibitors of coagulation factor xa. hookworm...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of physiology     Volume:  70     ISSN:  0066-4278     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-14     Completed Date:  2008-05-16     Revised Date:  2012-06-26    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329-55     Citation Subset:  IM    
Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure / physiology*
Homeostasis / physiology
Intracellular Signaling Peptides and Proteins
Protein-Serine-Threonine Kinases / genetics*,  metabolism*
Water-Electrolyte Balance / physiology*
Grant Support
//Howard Hughes Medical Institute
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; EC 2.7.1.-/Prkwnk4 protein, mouse; EC protein, mouse; EC Kinases; EC protein, human; EC protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A current view of the mammalian aquaglyceroporins.
Next Document:  Regulation of airway mucin gene expression.