Document Detail


Molecular phylogeny of Sporothrix schenckii.
MedLine Citation:
PMID:  16954256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathogenic dimorphic fungus Sporothrix schenckii is the agent responsible for sporotrichosis, an important fungal infection with a worldwide distribution. Little is known about the population structure of S. schenckii, although recent molecular and phenotypic data seem to demonstrate that different genetic lineages exist within this species. The aim of this study was to determine, by sequence analysis of three protein coding loci (chitin synthase, beta-tubulin, and calmodulin), whether this variability is due to species divergence or intraspecific diversity in S. schenckii. We included in the analysis 60 isolates (59 of clinical and 1 of environmental origin) of this species from a wide geographical range. DNA sequence data from the three nuclear regions were used in a phylogenetic analysis. The combined analysis of the three loci revealed the presence of three major clades, one grouping all of the European isolates, another with only Brazilian isolates, and the third with isolates from other South American countries and Africa. A total of 14 100% bootstrap-supported nodes were shown, 6 of them representing putative phylogenetic species. Our data also demonstrated that most of these species prevail in different geographical regions.
Authors:
Rita Marimon; Josepa Gené; Josep Cano; Luciana Trilles; Márcia Dos Santos Lazéra; Josep Guarro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  44     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-06     Completed Date:  2006-10-27     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3251-6     Citation Subset:  IM    
Affiliation:
Departament de Ciències Mèdiques Bàsiques, Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Carrer Sant Llorenç 21, 43201 Reus, Tarragona, Spain.
Data Bank Information
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MeSH Terms
Descriptor/Qualifier:
Brazil
Calmodulin / genetics
DNA, Fungal / analysis,  isolation & purification
Genotype
Humans
Molecular Sequence Data
Phylogeny*
Sequence Analysis, DNA
Sporothrix / classification*,  genetics*
Sporotrichosis / microbiology*
Tubulin / genetics
Chemical
Reg. No./Substance:
0/Calmodulin; 0/DNA, Fungal; 0/Tubulin
Comments/Corrections

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