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Molecular pharmacology of the mouse melatonin receptors MT(1) and MT(2).
MedLine Citation:
PMID:  22202844     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The main melatonin receptors are two G-protein coupled receptors named MT(1) and MT(2). Having described the molecular pharmacology of the human versions of these receptors, we turned to two of the three species most useful in studying melatonin physiology: rat and sheep (a diurnal species used to understand the relationship between circadian rhythm and depression). We also employed previously used compounds to describe the mouse melatonin receptors; despite the early cloning of mouse receptors, few molecular pharmacology studies on these receptors exist. To our surprise, we detected no major differences between the data obtained from mice and those from other species.
Authors:
Séverine Devavry; Céline Legros; Chantal Brasseur; William Cohen; Sophie-Pénélope Guenin; Philippe Delagrange; Benoît Malpaux; Christine Ouvry; Francis Cogé; Olivier Nosjean; Jean A Boutin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-20
Journal Detail:
Title:  European journal of pharmacology     Volume:  -     ISSN:  1879-0712     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
INRA, UMR85 Physiologie de la Reproduction et des Comportements, F-37380 Nouzilly, France; CNRS, UMR6175, F-37380 Nouzilly, France; Université de Tours, F-37041 Tours, France; Haras Nationaux, F-37380 Nouzilly, France; IFR135 Imagerie Fonctionnelle, F-37044 Tours, France; Biotechnologies, Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, F-78290 Croissy-sur-Seine, France.
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