| Molecular pharmacology of beta-adrenoceptors. | |
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MedLine Citation:
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PMID: 2427847 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of radioligand-binding studies has greatly advanced our knowledge of the molecular pharmacology of beta-adrenoceptors. With this technique it is possible for the first time to directly determine the tissue concentration of beta-adrenoceptors, and by this, the responsiveness of tissues to beta-adrenergic stimulation. One major insight into the molecular pharmacology of beta-adrenoceptors to come from radioligand-binding studies was that the tissue concentration of beta-adrenoceptors is not a fixed number, but is rather dynamically regulated by a variety of drugs, hormones, physiological and pharmacological conditions. Since changes in beta-adrenoceptors assessed in circulating lymphocytes of man mirror changes in density and functional responsiveness of the corresponding myocardial beta-adrenoceptors, alterations in beta-adrenoceptor function can be also studied in human beings. In addition, by means of radioligand-binding studies the coexistence of beta 1- and beta 2-adrenoceptors has been demonstrated in numerous tissues of various species, including human heart and lung. The detailed knowledge of distribution and regulation of beta-adrenoceptors should help to improve the individual effectiveness of drug treatment. |
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Authors:
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O E Brodde |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 8 Suppl 4 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1986 |
Date Detail:
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Created Date: 1986-10-20 Completed Date: 1986-10-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S16-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dihydroalprenolol / metabolism Humans Iodocyanopindolol Models, Biological Myocardium / analysis Pindolol / analogs & derivatives, metabolism Propanolamines / metabolism Radioligand Assay Receptors, Adrenergic, beta / metabolism* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Propanolamines; 0/Receptors, Adrenergic, beta; 13523-86-9/Pindolol; 58946-16-0/iodohydroxybenzylpindolol; 60106-89-0/Dihydroalprenolol; 72795-19-8/ICI 118551; 83498-72-0/Iodocyanopindolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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