Document Detail


Molecular pathophysiology of psoriasis and molecular targets of antipsoriatic therapy.
MedLine Citation:
PMID:  20003607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Psoriasis is a chronic inflammatory skin disease characterised by elevated red scaly plaques on specific body sites. Histologically, the plaques are defined by epidermal hyperplasia, epidermal and dermal infiltration by leukocytes, and changes in the dermal microvasculature. Differentiation and activation are disturbed in lesional psoriatic keratinocytes, and the pool of proliferating keratinocytes is increased, which is accompanied by enhanced production of proinflammatory cytokines, adhesion molecules and antimicrobial peptides. These changes in psoriatic keratinocytes are caused by altered expression of genes associated with epidermal differentiation, and by activation of signalling pathways involving signal transducer and activator of transcription 3 (STAT3), type I interferon (IFN) and mitogen-activated protein kinase (MAPK). The number of T cells, and myeloid and plasmacytoid dendritic cells (DCs) is markedly increased in psoriatic lesions. Myeloid DCs produce interleukin (IL)-23, tumour necrosis factor (TNF)-alpha and inducible nitric oxide synthase (iNOS), which are crucial cytokines in the pathogenesis of psoriasis. IL-23 stimulates the secretion of IL-22 by T helper 17 cells, and IL-22 induces epidermal hyperplasia. The crosstalk between keratinocytes and leukocytes via their proinflammatory cytokines creates the vicious circle of chronic skin inflammation seen in psoriasis. This suggests that optimal treatment of psoriasis needs to target pathogenic pathways in both leukocytes and keratinocytes.
Authors:
Emoke Rácz; Errol P Prens
Related Documents :
11501887 - Immune mechanisms in oral lichen planus.
16150577 - Protective roles of the skin against infection: implication of naturally occurring huma...
10545517 - Epidermal hla-dr and the enhancement of cutaneous reactivity to superantigenic toxins i...
19342087 - Uv-b radiation induces the expression of antimicrobial peptides in human keratinocytes ...
23065827 - Myeloid krüppel-like factor 4 deficiency augments atherogenesis in apoe-/- mice--brief ...
11895917 - Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosi...
Publication Detail:
Type:  Journal Article     Date:  2009-12-14
Journal Detail:
Title:  Expert reviews in molecular medicine     Volume:  11     ISSN:  1462-3994     ISO Abbreviation:  Expert Rev Mol Med     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-04-27     Revised Date:  2011-10-27    
Medline Journal Info:
Nlm Unique ID:  100939725     Medline TA:  Expert Rev Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  e38     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. e.racz@erasmusmc.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cytokines / adverse effects
Dendritic Cells / immunology
Dermatitis / metabolism
Humans
Interleukins / adverse effects,  therapeutic use*
Iron / metabolism
Keratinocytes / drug effects*,  physiology
Nitric Oxide Synthase Type II / metabolism
Psoriasis / drug therapy*,  metabolism,  pathology
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukins; 0/inferron; 0/interleukin-22; 7439-89-6/Iron; EC 1.14.13.39/NOS2 protein, human; EC 1.14.13.39/Nitric Oxide Synthase Type II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vestibular schwannoma: role of conservative management.
Next Document:  The bionomics of an invasive species Sitona lepidus during its establishment in New Zealand.