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Molecular pathology of Lewy body diseases.
MedLine Citation:
PMID:  19399218     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Lewy body diseases are characterized by the presence of Lewy bodies, alpha-synuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in these diseases. The analysis of inclusion body constituents gives additional information about pathways also involved in the pathology of synucleinopathies. Widespread mitochondrial dysfunction is very closely related to disease development. The impairment of protein degradation pathways, including both the ubiquitin-proteasome system and the autophagy-lysosome pathway also play an important role during the development of Lewy body diseases. Finally, differential expression changes of isoforms corresponding to genes primarily involved in Lewy body formation point to alternative splicing as another important mechanism in the development of Parkinson's disease, as well as dementia with Lewy bodies. The present paper attempts to give an overview of recent molecular findings related to the pathogenesis of Lewy body diseases.
Authors:
Katrin Beyer; Montserrat Domingo-Sàbat; Aurelio Ariza
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Publication Detail:
Type:  Journal Article     Date:  2009-02-26
Journal Detail:
Title:  International journal of molecular sciences     Volume:  10     ISSN:  1422-0067     ISO Abbreviation:  Int J Mol Sci     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2010-06-24     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  101092791     Medline TA:  Int J Mol Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  724-45     Citation Subset:  -    
Affiliation:
Department of Pathology, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona, Spain. katrinbeyer@hotmail.com <katrinbeyer@hotmail.com>
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