Document Detail

Molecular pathogenesis of pulmonary arterial hypertension.
MedLine Citation:
PMID:  18596905     Owner:  NLM     Status:  MEDLINE    
Recent investigations have suggested that it might be possible to reverse the pathology of pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal despite current treatments including i.v. prostacyclin. This review will address the cellular and molecular processes implicated in clinical, genetic, and experimental studies as underlying the pulmonary vascular abnormalities associated with PAH. Emerging treatments are aimed at inducing apoptosis of abnormal vascular cells that obstruct blood flow and at promoting regeneration of "lost" distal vasculature.
Marlene Rabinovitch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  118     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-03     Completed Date:  2008-09-25     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2372-9     Citation Subset:  AIM; IM    
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MeSH Terms
Bone Morphogenetic Protein Receptors, Type II / physiology
Hypertension, Pulmonary / etiology,  physiopathology*,  therapy
Inflammation Mediators / physiology
Ion Channels / physiology
Leukocyte Elastase / metabolism
Mesenchymal Stromal Cells / physiology
Models, Biological*
Vasodilator Agents / therapeutic use
Grant Support
Reg. No./Substance:
0/Inflammation Mediators; 0/Ion Channels; 0/Vasodilator Agents; EC Morphogenetic Protein Receptors, Type II; EC Elastase

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