Document Detail


Molecular pathogenesis and prevention of prostate cancer.
MedLine Citation:
PMID:  15160993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies in laboratory animals indicate inhibition of chemically-induced carcinoma by cystine-rich diets enhancing the cysteine-GSH antioxidant system. The progression of carcinoma of the prostate is also inhibited by these diets, which were later found to raise the level of GSH in the prostate epithelium of man. New data presented at the July 13, 2003 meeting of the American Association for Cancer Research indicates that higher levels of total cysteine in plasma may predict a reduced risk for breast cancer. This prospective investigation was conducted among 32,000 women in the Nurses Health study. The previously reported prostate cancer data appears then not to be strictly gender-related as the antioxidant role of the cysteine-GSH system may also apply to breast cancer prevention.
Authors:
Gustavo Bounous; Dieter Beer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anticancer research     Volume:  24     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2004 Mar-Apr
Date Detail:
Created Date:  2004-05-26     Completed Date:  2004-07-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  553-4     Citation Subset:  IM    
Affiliation:
Research and Development Department, Immunotec Research Ltd., Vaudreuil-Dorion, Quebec, Canada. jmolson@immunotec.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cysteine / metabolism*
Diet
Glutathione / metabolism*
Humans
Male
Oxidation-Reduction
Prostatic Neoplasms / metabolism*,  prevention & control*
Chemical
Reg. No./Substance:
52-90-4/Cysteine; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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