Document Detail


Molecular pathogenesis of mantle cell lymphoma.
MedLine Citation:
PMID:  23023712     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mantle cell lymphoma is a B cell malignancy in which constitutive dysregulation of cyclin D1 and the cell cycle, disruption of DNA damage response pathways, and activation of cell survival mechanisms contribute to oncogenesis. A small number of tumors lack cyclin D1 overexpression, suggesting that its dysregulation is always not required for tumor initiation. Some cases have hypermutated IGHV and stable karyotypes, a predominant nonnodal disease, and an indolent clinical evolution, which suggests that they may correspond to distinct subtypes of the disease. In this review, we discuss the molecular pathways that contribute to pathogenesis, and how improved understanding of these molecular mechanisms offers new perspectives for the treatment of patients.
Authors:
Pedro Jares; Dolors Colomer; Elias Campo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  122     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-01     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3416-23     Citation Subset:  AIM; IM    
Affiliation:
Hematopathology Section, Department of Pathology, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Apoptosis / genetics
B-Lymphocytes / pathology
Cell Transformation, Neoplastic / genetics*
Chromosomes, Human, Pair 11 / genetics*,  ultrastructure
Chromosomes, Human, Pair 14 / genetics*,  ultrastructure
Clone Cells / pathology
Complementarity Determining Regions / genetics
Cyclin D1 / biosynthesis,  physiology
DNA Repair / genetics
Disease Progression
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Genes, bcl-1
Germinal Center / pathology
Humans
Immunoglobulin Heavy Chains / genetics
Lymphoma, Mantle-Cell / drug therapy,  etiology,  genetics*,  pathology
Molecular Targeted Therapy
Neoplasm Invasiveness
Neoplasm Proteins / biosynthesis,  genetics*,  physiology
Neoplastic Stem Cells / pathology
Signal Transduction / genetics,  physiology
Stem Cell Niche
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/CCND1 protein, human; 0/Complementarity Determining Regions; 0/Immunoglobulin Heavy Chains; 0/Neoplasm Proteins; 136601-57-5/Cyclin D1
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