Document Detail

Molecular pathogenesis of cutaneous melanocytic neoplasms.
MedLine Citation:
PMID:  19400696     Owner:  NLM     Status:  MEDLINE    
Melanoma is the deadliest form of skin cancer without an effective treatment. An understanding of the genetic basis of melanoma has recently shed light on some of the mechanisms of melanomagenesis. This review explores the major genes involved in familial and sporadic cutaneous melanoma with an emphasis on CDKN2A, CDK4, MC1R, and MAPK pathway targets (e.g., RAS and BRAF), apoptosis regulators (e.g., BCL-2, AKT, and APAF-1), and the tumor-suppressor genes TP53 and PTEN. New directions for therapeutics based on our current knowledge of the genes implicated in melanoma are also discussed.
Nageatte Ibrahim; Frank G Haluska
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of pathology     Volume:  4     ISSN:  1553-4014     ISO Abbreviation:  -     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-29     Completed Date:  2009-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101275111     Medline TA:  Annu Rev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  551-79     Citation Subset:  IM    
Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
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MeSH Terms
Apoptosis / genetics
Cell Lineage / genetics
Cell Transformation, Neoplastic / genetics*,  metabolism,  pathology
Gene Expression Regulation, Neoplastic*
Genes, Tumor Suppressor
Genetic Predisposition to Disease
Melanocytes / metabolism*,  pathology
Melanoma / genetics*,  metabolism,  pathology,  therapy
Signal Transduction / genetics
Skin Neoplasms / genetics*,  metabolism,  pathology,  therapy

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