| Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis. | |
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MedLine Citation:
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PMID: 21349803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased iodide intake has been linked to the development of hypothyroidism and/or autoimmune thyroiditis in humans and animals, but the mechanisms involved remain poorly understood. Increased ingestion of iodide is likely to have pleiotropic effects on either metabolic or immunological processes. Within the latter domain, recent interest has been focused on two areas: a) the role of iodinated peptides in thyroglobulin (Tg)--the molecular site of biosynthesis and storage of iodotyrosines and iodothyronines--in triggering an autoimmune cascade, and b) the role of iodine-induced apoptosis/necrosis of thyrocytes in the disease process. This review presents a brief summary of recent findings in these research areas. |
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Authors:
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George Carayanniotis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Hormones (Athens, Greece) Volume: 10 ISSN: 1109-3099 ISO Abbreviation: Hormones (Athens) Publication Date: 2011 Jan-Mar |
Date Detail:
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Created Date: 2011-02-25 Completed Date: 2011-06-14 Revised Date: 2011-08-19 |
Medline Journal Info:
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Nlm Unique ID: 101142469 Medline TA: Hormones (Athens) Country: Greece |
Other Details:
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Languages: eng Pagination: 27-35 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada. gcarayan@mun.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / immunology, physiology Halogenation / physiology* Humans Iodine / metabolism*, pharmacology Models, Biological Signal Transduction / genetics, physiology Thyroglobulin / immunology, metabolism* Thyroid Gland / cytology, immunology, metabolism, pathology Thyroiditis, Autoimmune / etiology*, metabolism |
| Chemical | |
Reg. No./Substance:
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7553-56-2/Iodine; 9010-34-8/Thyroglobulin |
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