Document Detail


Molecular modeling, synthesis, and screening of new bacterial quorumsensing antagonists.
MedLine Citation:
PMID:  18156774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abstract A new series comprising 7 analogs of N-(sulfanyl ethanoyl)-L-HSL derivatives, 2 analogs of N-(fluoroalkanoyl)- L-HSL derivatives, N-(fluorosulfonyl)-L-HSL, and 2,2-dimethyl butanoyl HSL were synthesized using a solid-phase organic synthesis method. Each of the 11 synthesized compounds was analyzed using NMR and mass spectroscopies, and molecular modeling studies of the 11 ligands were performed using SYBYL packages. Thereafter, a bacterial test was designed to identify their quorum-sensing inhibition activity and antifouling efficacy. Most of the synthesized compounds were found to be effective as quorum-sensing antagonists, where antagonist screening revealed that 10 among the 11 synthesized ligands were able to antagonize the quorum sensing of A. tumefaciens.
Authors:
Cheoljin Kim; Jaeeun Kim; Hyung-Yeon Park; Robert J C McLean; Chan Kyung Kim; Jongho Jeon; Song-Se Yi; Young Gyu Kim; Yoon-Sik Lee; Jeyong Yoon
Related Documents :
22420734 - Ring enlargement versus selenoetherification on the reaction of lactam-tethered allenol...
22390834 - Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
22893624 - Bioactivity-guided isolation of antiosteoporotic compounds from ligustrum lucidum.
22541394 - Appraisal of gaba and paba as linker: design and synthesis of novel benzamide based his...
16254824 - Isolation of new rotenoids from boerhaavia diffusa and evaluation of their effect on in...
22519644 - Oxidation state and symmetry of magnesia supported pd13ox nanocatalysts influence activ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of microbiology and biotechnology     Volume:  17     ISSN:  1017-7825     ISO Abbreviation:  J. Microbiol. Biotechnol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431852     Medline TA:  J Microbiol Biotechnol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1598-606     Citation Subset:  IM    
Affiliation:
School of Chemical & Biological Engineering, Seoul National University, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
4-Butyrolactone / analogs & derivatives*,  chemical synthesis,  chemistry,  pharmacology
Anti-Bacterial Agents / chemical synthesis,  chemistry,  pharmacology*
Biofilms / drug effects
Biological Assay
Drug Design
Models, Molecular
Pseudomonas aeruginosa / drug effects*,  metabolism
Quorum Sensing / drug effects*
Rhizobium / drug effects*,  metabolism
Small Molecule Libraries / pharmacology
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Small Molecule Libraries; 1192-20-7/homoserine lactone; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Fatty acid and carotenoid production by Sporobolomyces ruberrimus when using technical glycerol and ...
Next Document:  Bacterial beta-lactamase fragmentation complementation strategy can be used as a method for identify...