Document Detail

Molecular modeling directed by an interfacial test apparatus for the evaluation of protein and polymer ingredient function in situ.
MedLine Citation:
PMID:  18454546     Owner:  NLM     Status:  MEDLINE    
A simplified apparatus is described that measures the damping of a suspended measuring device. The movement of the device (bob) is damped by the properties of the air-water surface adsorbed material. Its value lies in describing the surface chemomechanical properties of ingredients and excipients used in food, nutraceutical, cosmetic (cosmeceutical), and natural drug-food product formulations that traverse the food sciences. Two surfactants, two food and drug-grade polymers, and five naturally occurring food and serum proteins were tested and used to estimate and model interfacial viscoelasticity. Equilibration times of >15 min were found to give sufficiently stable interfaces for routine assessment. The viscoelasticity of the air-water interface was estimated with reference to model solutions. These model solutions and associated self-assembled interfacial nanostructured adsorbed layers were fabricated using a preliminary screening process with the aid of a specialized foaming apparatus ( C(300) values), surface tension measurements (23-73 mN/m), and referential surface shear and dilation experiments. The viscoelasticity measured as a percentage of surface damping ( D) of a pendulum was found to range from 1.0 to 22.4% across the samples tested, and this represented interfacial viscosities in the range of 0-4630 microNs/m. The technique can distinguish between interfacial compositions and positions itself as an easily accessible valuable addition to tensiometric and analytical biochemistry-based techniques.
George W Collins; Avani Patel; Alan Dilley; Dipak K Sarker
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Publication Detail:
Type:  Journal Article     Date:  2008-05-03
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-22     Completed Date:  2008-07-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3846-55     Citation Subset:  IM    
Chemical Biology Research Group, School of Pharmacy and Biomolecular Sciences, The University of Brighton, Moulsecoomb Science Campus, Lewes Road, Brighton BN2 4GJ, United Kingdom.
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MeSH Terms
Chemistry, Physical / instrumentation*
Cosmetics / analysis
Dietary Supplements / analysis
Emulsions / chemistry
Food Analysis / instrumentation
Polymers / chemistry*
Proteins / chemistry*
Rheology / instrumentation
Surface Tension
Reg. No./Substance:
0/Cosmetics; 0/Emulsions; 0/Polymers; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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