| Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept. | |
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MedLine Citation:
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PMID: 16329189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Molecular mimicry is defined as similar structures shared by molecules from dissimilar genes or by their protein products. Either several linear amino acids or their conformational fit may be shared, even though their origins are separate. Hence, during a viral or microbe infection, if that organism shares cross-reactive epitopes for B or T cells with the host, then the response to the infecting agent will also attack the host, causing autoimmune disease. A variation on this theme is when a second, third, or repeated infection(s) shares cross-reactive B or T cell epitopes with the first (initiating) virus but not necessarily the host. In this instance, the secondary infectious agents increase the number of antiviral/antihost effector antibodies or T cells that potentiate or precipitate the autoimmune assault. The formation of this concept initially via study of monoclonal antibody or clone T cell cross-recognition in vitro through its evolution to in vivo animal models and to selected human diseases is explored in this mini-review. |
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Authors:
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M B A Oldstone |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current topics in microbiology and immunology Volume: 296 ISSN: 0070-217X ISO Abbreviation: Curr. Top. Microbiol. Immunol. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-01-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0110513 Medline TA: Curr Top Microbiol Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 1-17 Citation Subset: IM |
Affiliation:
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Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA. mbaobo@scripps.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Autoantibodies / biosynthesis Autoantigens / genetics Autoimmune Diseases / etiology*, immunology, microbiology Disease Models, Animal Epitopes / genetics Humans Infection / immunology* Models, Immunological Molecular Mimicry / immunology* Molecular Sequence Data T-Lymphocytes / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI-009484/AI/NIAID NIH HHS; AI-036222/AI/NIAID NIH HHS; AI-045927/AI/NIAID NIH HHS; DK-058541/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Autoantigens; 0/Epitopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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