Document Detail


Molecular mimicry between GQ1b ganglioside and lipopolysaccharides of Campylobacter jejuni isolated from patients with Fisher's syndrome.
MedLine Citation:
PMID:  7526777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We isolated Campylobacter jejuni from 2 patients with Fisher's syndrome subsequent to enteritis. Crude lipopolysaccharide fractions were extracted from the bacteria and separated by thin-layer chromatography. Monoclonal antibodies to GQ1b ganglioside (GMR13 and 7F5) reacted with both lipopolysaccharide fractions, indicating that the lipopolysaccharides bear the GQ1b epitope. This is the first report of molecular mimicry between neural tissue components and the antecedent infectious agents of Fisher's syndrome.
Authors:
N Yuki; T Taki; M Takahashi; K Saito; H Yoshino; T Tai; S Handa; T Miyatake
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  36     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-13     Completed Date:  1994-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  791-3     Citation Subset:  IM    
Affiliation:
Department of Neurology, Tokyo Medical and Dental University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal
Campylobacter Infections / immunology*
Campylobacter jejuni / immunology*,  isolation & purification
Cerebellar Ataxia / immunology*,  microbiology
Chromatography, Thin Layer
Epitopes
Gangliosides / immunology*
Humans
Lipopolysaccharides / immunology*
Male
Molecular Mimicry*
Ophthalmoplegia / immunology,  microbiology
Syndrome
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Epitopes; 0/Gangliosides; 0/Lipopolysaccharides; 68652-37-9/GQ1b ganglioside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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