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Molecular mechanisms underlying nutrient detection by incretin-secreting cells.
MedLine Citation:
PMID:  20204054     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are secreted postprandially from intestinal K- and L-cells, respectively. As incretins, these hormones stimulate insulin secretion from the pancreatic beta-cell, and have independently been implicated in the control of food intake and lipid metabolism. Whilst the enteroendocrine cells producing GIP and GLP-1 are therefore attractive targets for the treatment of diabetes and obesity, our understanding of their physiology is fairly limited. The mechanisms employed to sense the arrival of carbohydrate, fat and protein in the gut lumen have been investigated using organ perfusion techniques, primary epithelial cultures and cell line models. The recent development of mice with fluorescently labeled GIP or GLP-1-expressing cells is now enabling the use of single cell techniques to investigate stimulus-secretion coupling mechanisms. This review will focus on the current knowledge of the molecular machinery underlying nutrient sensing within K- and L-cells.
Authors:
Frank Reimann
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  International dairy journal / published in association with the International Dairy Federation     Volume:  20     ISSN:  0958-6946     ISO Abbreviation:  -     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101213739     Medline TA:  Int Dairy J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  236-242     Citation Subset:  -    
Affiliation:
Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.
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