Document Detail

Molecular mechanisms of renin release.
MedLine Citation:
PMID:  1705619     Owner:  NLM     Status:  MEDLINE    
Renin secretion from renal juxtaglomerular cells is controlled by the intrarenal blood pressure, sodium chloride load of the organism, sympathetic nerve activity, and a number of hormones. The mechanisms by which these parameters exert their effects are not well understood. However, it is reasonable to assume that they act via signal transduction systems, implying the role of second messenger molecules in the control of renin secretion. This article summarizes present knowledge about the cellular mechanisms of renin secretion. Moreover, current concepts about the mechanisms by which the blood pressure and the sodium chloride load could influence renin secretion are discussed.
A Kurtz; H Scholz; R della Bruna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  16 Suppl 4     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-04-08     Completed Date:  1991-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S1-7     Citation Subset:  IM    
Physiologisches Institut der Universität Zürich, Switzerland.
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MeSH Terms
Angiotensin II / physiology
Blood Pressure / drug effects
Calcium / physiology
Juxtaglomerular Apparatus / anatomy & histology,  drug effects,  physiology*
Renin / secretion*
Sodium Chloride / pharmacology
Reg. No./Substance:
11128-99-7/Angiotensin II; 7440-70-2/Calcium; 7647-14-5/Sodium Chloride; EC

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