| Molecular mechanisms of recovery from acute renal failure. | |
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MedLine Citation:
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PMID: 12907887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Despite technological advances in renal replacement therapy over the past few years, acute renal failure in the intensive care unit remains associated with high morbidity and mortality rates. In this article I review recent research aimed at elucidating mechanisms of renal recovery from acute injury. DESIGN: Review of the literature. CONCLUSIONS: A number of peptide growth hormones are reviewed, including epidermal growth factor, insulin-like growth factor-1, thyroxine, hepatocyte growth factor, and bone morphogenetic protein-7 promote renal regeneration in model systems. Unfortunately, despite promising studies in animal models of toxin and ischemia-induced acute tubular necrosis, human studies have not shown any clinical benefit. However, several of these molecules have not been studied in clinical trials. Existing pharmacologic strategies have a limited role in renal recovery. Finally, several recent studies have focused on the effects of renal replacement therapy on renal recovery, but additional studies are needed to confirm and extend these results. |
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Authors:
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Kathleen D Liu |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical care medicine Volume: 31 ISSN: 0090-3493 ISO Abbreviation: Crit. Care Med. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-08 Completed Date: 2003-09-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: S572-81 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Unicversity of California, San Francisco, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Critical Care* Critical Illness* Epithelial Cells / physiology Growth Substances / physiology Humans Kidney Failure, Acute / physiopathology*, therapy Kidney Tubules / physiology Necrosis Regeneration / physiology* Renal Replacement Therapy |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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