| Molecular mechanisms and potential functions of histone demethylases. | |
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MedLine Citation:
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PMID: 22473470 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Histone modifications are thought to regulate chromatin structure, transcription and other nuclear processes. Histone methylation was originally believed to be an irreversible modification that could only be removed by histone eviction or by dilution during DNA replication. However, the isolation of two families of enzymes that can demethylate histones has changed this notion. The biochemical activities of these histone demethylases towards specific Lys residues on histones, and in some cases non-histone substrates, have highlighted their importance in developmental control, cell-fate decisions and disease. Their ability to be regulated through protein-targeting complexes and post-translational modifications is also beginning to shed light on how they provide dynamic control during transcription. |
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Authors:
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Susanne Marije Kooistra; Kristian Helin |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-04 |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: - ISSN: 1471-0080 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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