| Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. | |
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MedLine Citation:
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PMID: 20025935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Defects in pituitary gland organogenesis are sometimes associated with congenital anomalies that affect head development. Lesions in transcription factors and signaling pathways explain some of these developmental syndromes. Basic research studies, including the characterization of genetically engineered mice, provide a mechanistic framework for understanding how mutations create the clinical characteristics observed in patients. Defects in BMP, WNT, Notch, and FGF signaling pathways affect induction and growth of the pituitary primordium and other organ systems partly by altering the balance between signaling pathways. The PITX and LHX transcription factor families influence pituitary and head development and are clinically relevant. A few later-acting transcription factors have pituitary-specific effects, including PROP1, POU1F1 (PIT1), and TPIT (TBX19), while others, such as NeuroD1 and NR5A1 (SF1), are syndromic, influencing development of other endocrine organs. We conducted a survey of genes transcribed in developing mouse pituitary to find candidates for cases of pituitary hormone deficiency of unknown etiology. We identified numerous transcription factors that are members of gene families with roles in syndromic or non-syndromic pituitary hormone deficiency. This collection is a rich source for future basic and clinical studies. |
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Authors:
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S W Davis; F Castinetti; L R Carvalho; B S Ellsworth; M A Potok; R H Lyons; M L Brinkmeier; L T Raetzman; P Carninci; A H Mortensen; Y Hayashizaki; I J P Arnhold; B B Mendonça; T Brue; S A Camper |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-12-16 |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 323 ISSN: 1872-8057 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-20 Completed Date: 2010-08-20 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
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Languages: eng Pagination: 4-19 Citation Subset: IM |
Affiliation:
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University of Michigan Medical School, Ann Arbor, MI 41809-5618, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Communication / genetics, physiology Female Gene Expression Regulation, Developmental* Genes, Developmental* Homeodomain Proteins / genetics, physiology Human Growth Hormone / deficiency, physiology Humans Male Mice Organogenesis / genetics* Pituitary Gland / growth & development* Transcription Factors / genetics, physiology |
| Grant Support | |
ID/Acronym/Agency:
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NRSA F32-HD046300/HD/NICHD NIH HHS; R01 HD034283-14/HD/NICHD NIH HHS; R01 HD034283-15/HD/NICHD NIH HHS; R01HD034283/HD/NICHD NIH HHS; R37 HD030428-17/HD/NICHD NIH HHS; R37 HD030428-19/HD/NICHD NIH HHS; R37HD030428/HD/NICHD NIH HHS; T32 HD07048/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/Transcription Factors; 12629-01-5/Human Growth Hormone |
| Comments/Corrections | |
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