| Molecular mechanisms of pancreatic injury. | |
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MedLine Citation:
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PMID: 21844752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Despite being a subject of much scientific scrutiny, the pathogenesis of acute pancreatitis is still not well understood. This article reviews recent advances in our understanding of acute pancreatitis. RECENT FINDINGS: Zymogen activation, observed within acini early during acute pancreatitis for a long time, was shown to be sufficient to induce acute pancreatitis. Another key early event, NFκB activation, has previously been shown to induce acute pancreatitis. The relationship between these two key early steps is beginning to be clarified. Mechanisms of zymogen activation - pathologic calcium signaling, pH changes, colocalization and autophagy, and of NFκB activation have been investigated intensively along with potential therapeutic targets both upstream and downstream of these key events. Additional key findings have been elucidation of the role of bioenergetics and the dual role of oxidative stress in acute pancreatitis, recognition of endoplasmic reticulum stress as an early step and the status of duct cells as important entities in pancreatic injury. SUMMARY: Current findings have provided further insight into the roles and mechanisms of zymogen activation and inflammatory pathways in pancreatic injury. Future studies, which will be of great importance in identifying therapeutic targets, are being undertaken to establish the relative contributions of these pathways during acute pancreatitis. |
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Authors:
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Raghuwansh P Sah; Ashok Saluja |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current opinion in gastroenterology Volume: 27 ISSN: 1531-7056 ISO Abbreviation: Curr. Opin. Gastroenterol. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-16 Completed Date: 2012-01-13 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 8506887 Medline TA: Curr Opin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 444-51 Citation Subset: IM |
Affiliation:
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Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endoplasmic Reticulum / metabolism, physiology Energy Metabolism Enzyme Precursors / metabolism*, physiology Humans NF-kappa B / metabolism*, physiology Oxidative Stress Pancreatitis / etiology*, metabolism*, physiopathology Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK058694/DK/NIDDK NIH HHS; R01 DK058694/DK/NIDDK NIH HHS; R01 DK092145-02/DK/NIDDK NIH HHS; R01 DK093047/DK/NIDDK NIH HHS; R01 DK093047-02/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Precursors; 0/NF-kappa B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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