Document Detail

Molecular mechanisms of maculopapular exanthema.
MedLine Citation:
PMID:  19398898     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Maculopapular exanthema is a common cutaneous manifestation of many diseases produced by several agents able to activate the immune system, the most common of which are drugs and viruses. In spite of its high frequency, knowledge of the molecular mechanisms involved remains scarce.
RECENT FINDINGS: The cytokine patterns in maculopapular exanthema have a Th1 or Th0 pattern, according to whether the reaction is induced by a drug or a virus, respectively. Additionally, the involvement of CD4 T-lymphocytes with cytotoxic capabilities has been shown in the former. Different chemokines and their receptors are also involved in skin homing, such as CCL20, CCL27, CXCL9 or CXCL10, and oxidative stress can help exacerbate the symptoms.
SUMMARY: These findings may be very important for the diagnostic evaluation of these entities and for the development of new tools for diagnosis and treatment.
Tahia D Fernández; Gabriela Canto; Miguel Blanca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  22     ISSN:  1473-6527     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-05-14     Revised Date:  2012-01-31    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  272-8     Citation Subset:  IM    
Research Laboratory for Allergic Diseases, Carlos Haya Hospital-Fundacion IMABIS, Malaga, Spain.
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MeSH Terms
CD4-Positive T-Lymphocytes / immunology
Cytokines / immunology
Drug Hypersensitivity / complications*
Oxidative Stress
Skin / pathology*
Virus Diseases / complications*
Reg. No./Substance:

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