Document Detail


Molecular mechanisms of maculopapular exanthema.
MedLine Citation:
PMID:  19398898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Maculopapular exanthema is a common cutaneous manifestation of many diseases produced by several agents able to activate the immune system, the most common of which are drugs and viruses. In spite of its high frequency, knowledge of the molecular mechanisms involved remains scarce.
RECENT FINDINGS: The cytokine patterns in maculopapular exanthema have a Th1 or Th0 pattern, according to whether the reaction is induced by a drug or a virus, respectively. Additionally, the involvement of CD4 T-lymphocytes with cytotoxic capabilities has been shown in the former. Different chemokines and their receptors are also involved in skin homing, such as CCL20, CCL27, CXCL9 or CXCL10, and oxidative stress can help exacerbate the symptoms.
SUMMARY: These findings may be very important for the diagnostic evaluation of these entities and for the development of new tools for diagnosis and treatment.
Authors:
Tahia D Fernández; Gabriela Canto; Miguel Blanca
Related Documents :
7542298 - Direct and indirect control of t-cell activation by keratinocytes.
2191058 - The biology of the t-cell antigen receptor and its role in the skin immune system.
23192518 - Combat or surveillance? evaluation of the heterogeneous inflammatory breast cancer micr...
1358928 - Response of aged versus young skin to intradermal administration of interferon gamma.
20201008 - Il-1: discoveries, controversies and future directions.
2401568 - Protective immunization against experimental bacteroides (porphyromonas) gingivalis inf...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  22     ISSN:  1473-6527     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-04-28     Completed Date:  2009-05-14     Revised Date:  2012-01-31    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  272-8     Citation Subset:  IM    
Affiliation:
Research Laboratory for Allergic Diseases, Carlos Haya Hospital-Fundacion IMABIS, Malaga, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
CD4-Positive T-Lymphocytes / immunology
Cytokines / immunology
Drug Hypersensitivity / complications*
Humans
Oxidative Stress
Skin / pathology*
Virus Diseases / complications*
Chemical
Reg. No./Substance:
0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation...
Next Document:  Squamous cell carcinoma of the external auditory canal: long-term clinical outcomes using surgery an...